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KMID : 0043320010240030214
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Archives of Pharmacal Research
2001 Volume.24 No. 3 p.214 ~ p.218
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Comparisons between white Ginseng Radix and Rootlet for Antidiabetic Activity and Mechanism in KKAy Mice
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Jang EJ
Lee YJ/Chung SJ/Shim CK
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Abstract
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The mechanisms responsible for the antidiabetic Activity of both the white ginseng radix (Ginseng Radix Alba,GRA) and the rootlet (Ginseng Radix Palva, CRf) were investifated. A fter a tour week oral administration, the fasting blood glucose levels in the CRh- and CRP-treated groups were lower whets compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activites, in addition to PPAR-gamma expression in adipose tissue were examined. The results strongly that CRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal g1ucose absorption and inhibiting hepatic glucose-6-phosphatase, and CRP through the upregulation oi adipocytic PPAR-gamma protein expression as well as inhibiting intestlnal glucose absorption.
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